| Description | Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency. |
| Synonyms | PKR-IN-1 |
| molecular weight | 450.55 |
| Molecular formula | C24H26N4O3S |
| CAS | 1260075-17-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 3.67 mg/mL (8.14 mM) |
| References | 1. C Kung. Activators of pyruvate kinase M2 and methods of treating disease. PCT Int. Appl. WO 2013056153 A1. 2. FG Salituro et al. Preparation of aroylpiperazines and related compounds as pyruvate kinase M2 modulators useful in treatment of cancer. U.S. Pat. Appl. US 201200331307 A1. |