| Description | MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins. |
| In vitro | AI-10-49 对 inv(16)-阳性细胞系 ME-1 表现出特异性生长抑制作用。它选择性地结合到 CBFβ-SMMHC，破坏其与 RUNX1 的结合，并恢复 RUNX1 的转录活性。[1] |
| Synonyms | ALLN, Ac-LLnL-CHO, Calpain inhibitor I, Calpain inhibitor-1, MG101, 钙蛋白酶抑制剂I |
| molecular weight | 383.53 |
| Molecular formula | C20H37N3O4 |
| CAS | 110044-82-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | Ethanol: 76 mg/mL (198.15 mM) DMSO: 60 mg/mL (156.44 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Hiwasa T, et al. Carcinogenesis. 1990, 11(1), 75-80. 2. Inoue S, et al. J Biol Chem. 1991, 266(20), 13311-13317. |