| Description | Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase.Methyl rosmarinate shows antioxidative, and antifungal activities. It has inhibitory activities against tyrosinase, α±-glucosidase, and matrix metalloproteinase-1 (MMP-1). |
| In vitro | 初始微量滴定测定显示了化合物对S. carnosus LTH1502的活性，而具有不同链长的酯类，如RA、n-Methyl rosmarinate (RE1)、n-dodecyl rosmarinate (RE12)和n-octadecyl rosmarinate (RE18)则在对S. carnosus LTH1502的时间杀灭试验中被使用。化合物在对数生长期加入浓度为0.75 mM，在指数生长期为5 mM，在静止期为10 mM。RA在滞后期和指数生长期无效果，但在静止期减少了细胞计数。相比之下，RE1和RE12在三个生长期都能减少细胞数量，且RE12的减少速度最快。RE18的添加无论在何种生长期都不影响。 |
| Target activity | Tyrosinase:0.28 mM |
| molecular weight | 374.34 |
| Molecular formula | C19H18O8 |
| CAS | 99353-00-1 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 74.88 mg/mL (200 mM ), Sonication is recommended. |
| References | 1. Impact of fatty acid chain length of rosmarinate esters on their antimicrobial activity against Staphylococcus carnosus LTH1502 and Escherichia coli K-12 LTH4263.J Food Prot. 2013 Sep;76(9):1539-48. |