| Description | Metacavir (PNA) is a novel nucleoside reverse transcriptase inhibitor, a deoxyguanosine analog, with anti-hepatitis B virus (HBV) activity and mitochondrial toxicity, which can be used to study HBV infection. |
| Synonyms | PNA |
| molecular weight | 265.27 |
| Molecular formula | C11H15N5O3 |
| CAS | 120503-45-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Ide H, et al. Modeling Developmental Changes in Caffeine Clearance Considering Differences between Pre- and Postnatal Period. Biol Pharm Bull. 2024;47(4):861-867. 2. Jaime J,et al. Development and prenatal exposure to androgens alter potassium currents in gonadotropin-releasing hormone neurons from female mice. J Neuroendocrinol. 2024 Mar;36(3):e13373. 3. Chen W,et al. Targeted Delivery of Peptide Nucleic Acid by Biomimetic Nanoparticles Based on Extracellular Vesicle-coated Mesoporous Silica Nanoparticles. Curr Med Chem. 2024 Jan 20. 4. Zhang P,et al. In vitro mitochondrial toxicity of metacavir, a new nucleoside reverse transcriptase inhibitor for treatment of hepatitis B virus. Antimicrob Agents Chemother. 2010 Nov;54(11):4887-92. doi: 10.1128/AAC.00794-10. Epub 2010 Aug 30. |