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Me-Indoxam

CAS No.: 172732-62-6

Me-Indoxam is an inhibitor of sPLA2. It has no effect on arachidonic acid release and platelet activating factor synthes
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Description Me-Indoxam is an inhibitor of sPLA2. It has no effect on arachidonic acid release and platelet activating factor synthesis.
Synonyms Methyl indoxam, Methyl-indoxam
molecular weight 442.46
Molecular formula C26H22N2O5
CAS 172732-62-6
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. Granata F, Frattini A, Loffredo S, Staiano RI, Petraroli A, Ribatti D, Oslund R, Gelb MH, Lambeau G, Marone G, Triggiani M. Production of vascular endothelial growth factors from human lung macrophages induced by group IIA and group X secreted phospholipases A2. J Immunol. 2010 May 1;184(9):5232-41. doi: 10.4049/jimmunol.0902501. Epub 2010 Mar 31. PubMed PMID: 20357262; PubMed Central PMCID: PMC3073479. 2. Triggiani M, Giannattasio G, Calabrese C, Loffredo S, Granata F, Fiorello A, Santini M, Gelb MH, Marone G. Lung mast cells are a source of secreted phospholipases A2. J Allergy Clin Immunol. 2009 Sep;124(3):558-65, 565.e1-3. doi: 10.1016/j.jaci.2009.04.035. Epub 2009 Jul 9. PubMed PMID: 19541351; PubMed Central PMCID: PMC2788562. 3. Giannattasio G, Lai Y, Granata F, Mounier CM, Nallan L, Oslund R, Leslie CC, Marone G, Lambeau G, Gelb MH, Triggiani M. Expression of phospholipases A2 in primary human lung macrophages: role of cytosolic phospholipase A2-alpha in arachidonic acid release and platelet activating factor synthesis. Biochim Biophys Acta. 2009 Feb;1791(2):92-102. doi: 10.1016/j.bbalip.2008.12.002. Epub 2008 Dec 16. PubMed PMID: 19130898; PubMed Central PMCID: PMC2676353. 4. Touaibia M, Djimdé A, Cao F, Boilard E, Bezzine S, Lambeau G, Redeuilh C, Lamouri A, Massicot F, Chau F, Dong CZ, Heymans F. Inhibition of secreted phospholipase A2. 4-glycerol derivatives of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one with broad activities. J Med Chem. 2007 Apr 5;50(7):1618-26. Epub 2007 Mar 3. PubMed PMID: 17335183.