| Description | LY 181984 is an sulfonylurea with antitumor properties. |
| Synonyms | LY181984, LY-181984, MPCU |
| molecular weight | 324.78 |
| Molecular formula | C14H13ClN2O3S |
| CAS | 3955-50-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Chueh PJ, Kim C, Cho N, Morré DM, Morré DJ. Molecular cloning and characterization of a tumor-associated, growth-related, and time-keeping hydroquinone (NADH) oxidase (tNOX) of the HeLa cell surface. Biochemistry. 2002 Mar 19;41(11):3732-41. PubMed PMID: 11888291. 2. Morré DJ, Chueh PJ, Lawler J, Morré DM. The sulfonylurea-inhibited NADH oxidase activity of HeLa cell plasma membranes has properties of a protein disulfide-thiol oxidoreductase with protein disulfide-thiol interchange activity. J Bioenerg Biomembr. 1998 Oct;30(5):477-87. PubMed PMID: 9932650. 3. Morré DJ, Wu LY, Morré DM. Response of a cell-surface NADH oxidase to the antitumor sulfonylurea N-(4-methylphenylsulfonyl)-N'-(4-chlorophenylurea) (LY181984) modulated by redox. Biochim Biophys Acta. 1998 Mar 2;1369(2):185-92. PubMed PMID: 9518604. 4. Chern JW, Leu YL, Wang SS, Jou R, Lee CF, Tsou PC, Hsu SC, Liaw YC, Lin HM. Synthesis and cytotoxic evaluation of substituted sulfonyl-N-hydroxyguanidine derivatives as potential antitumor agents. J Med Chem. 1997 Jul 4;40(14):2276-86. PubMed PMID: 9216847. |