| Description | MDL 72527 (N1,N4-Di(buta-2,3-dien-1-yl)butane-1,4-diamine dihydrochloride) is a polyamine oxidase (POA) inhibitor |
| In vivo | 在没有CRP的情况下，血小板暴露于MDL-72527并未显著改变[Ca2+]i、P-选择素的含量、αIIbβ3整合素的含量、ROS、annexin-V结合以及前向散射。当添加2-5 μg/ml的CRP后，观察到[Ca2+]i、P-选择素的含量、αIIbβ3整合素的激活、ROS的含量、annexin-V结合以及聚集显著增加，同时前向散射显著减少，而这些效应在MDL-72527的存在下被显著削弱或几乎完全消除。MDL-72527是一种强效的抑制血小板激活、凋亡和聚集的化合物。 |
| Synonyms | N1,N4-Di(buta-2,3-dien-1-yl)butane-1,4-diamine dihydrochloride |
| molecular weight | 265.22 |
| Molecular formula | C12H22Cl2N2 |
| CAS | 93565-01-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 20 mg/ml (75.41 mM) |
| References | 1. Guoxing, Liu, Hang, et al. Effect of Lysosomotropic Polyamineoxidase Inhibitor MDL-72527 on Platelet Activation.[J]. Cellular Physiology & Biochemistry International Journal of Experimental Cellular Physiology Biochemistry & Pharmacology, 2016. |