| Description | MCU-i11 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth. |
| In vitro | 在小鼠胚胎成纤维细胞（MEFs）、MDA-MB-231和HEK293T细胞系中，经10 μM化合物处理后测量了线粒体Ca2+的摄取。结果显示，MCU-i11在所有测试的细胞系中减少了线粒体Ca2+摄取，表明存在一个保守的机制。MCU-i11对细胞活性无影响。[1] |
| molecular weight | 532.61 |
| Molecular formula | C28H28N4O5S |
| CAS | 902903-59-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (84.49 mM) |
| References | 1. Giulia Di Marco, et al. A High-Throughput Screening Identifies MICU1 Targeting Compounds. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6. |