| Description | MCI, a chemical compound demonstrating significant anti-inflammatory effects, particularly in collagen-induced arthritis (CIA) models, modulates inflammation through macrophage reprogramming by enhancing ROS scavenging and promoting COX-2 downregulation. It effectively inhibits COX-2, exhibiting an IC50 of 1.23 μM. Additionally, MCI holds potential for research applications in rheumatoid arthritis (RA) [1]. |
| In vitro | MCI（8 μM，2 h）抑制了LPS激活的RAW 264.7细胞中的ROS产生和COX-2表达，促进了从M1型向M2型巨噬细胞的转变[1]。 |
| In vivo | MCI（剂量为1.05 mg/kg，关节腔内注射，每隔两天一次，共计18天）能够有效预防类风湿性关节炎（RA）的发展，并展现出显著的抗炎效果[1]。 |
| Target activity | COX-2:1.23 μM |
| molecular weight | 934.39 |
| Molecular formula | C45H52ClN7O13 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |