| Description | Magnesium Lithospermate B is a natural product activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress, it can protecte cardiomyocytes from ischemic injury through specific inhibition of TAB1-p38 apoptosis signaling.improves renal failure. |
| In vitro | Magnesium Lithospermate B (MLB) 剂量依赖性地抑制了小胶质细胞的激活并减少了神经元凋亡。Western blot 分析表明，MLB 降低了炎症细胞因子TNF-和促凋亡蛋白裂解caspase-3的表达。更重要的是，MLB 增加了SIRT1的表达，同时抑制了NF-B的乙酰化。此外，用sirtinol（SIRT1的选择性抑制剂）预处理可以逆转MLB在SAH后的所有上述效果[1]。 |
| In vivo | Magnesium Lithospermate B (MLB)，一种从丹参中提取的活性成分，在多种中枢神经系统损伤中表现出神经保护作用。研究表明，MLB的给药显著减轻了蛛网膜下腔出血(SAH)[1]后的脑水肿和神经功能障碍。 |
| Animal experiments | Adult male Sprague-Dawley rats were subjected to an endovascular perforation process to produce an SAH model.?MLB was administrated intraperitoneally at 30min after SAH with a dose of 25mg/kg or 50mg/kg[1]. |
| Synonyms | 丹參酸B鎂, Monomethyl lithospermate B, 丹参酸 B 镁, Lithospermate B |
| molecular weight | 740.9 |
| Molecular formula | C36H28MgO16 |
| CAS | 122021-74-3 |
| Storage | store at low temperature|Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 7.41 mg/mL (10 mM) |
| References | 1. Yucong P , Pingyou H , Linfeng F , et al. Neuroprotective Effects of Magnesium Lithospermate B against Subarachnoid Hemorrhage in Rats[J]. The American Journal of Chinese Medicine, 2018, 46:1-17. 2. Zhang Z , Zichen W , Wei R , et al. Magnesium lithospermate B promotes proliferation and differentiation of neural stem cells in vitro and enhances neurogenesis in vivo[J]. Tissue & Cell, 2018, 53:8-14. |