| Description | M62812 (free base), a Toll-like receptor 4 (TLR4) signal transduction inhibitor, suppresses activation of endothelial cells and leukocytes and prevents lethal septic shock in mice. It is utilized in sepsis research [1]. |
| In vitro | M62812 (0-10 μg/ml) 能够有效抑制 LPS 在人血管内皮细胞及外周单核细胞中诱导的炎性细胞因子、粘附分子以及促凝活性的表达增强 [1]。 |
| In vivo | M62812（静脉注射；10-20 mg/kg；单次）可在小鼠的d-半乳糖胺致敏内毒素休克模型中保护小鼠不致死亡，并能减少炎症和凝血指标[1]。M62812（20 mg/kg/日）用于小鼠盲肠结扎和穿刺模型能有效预防死亡[1]。 |
| molecular weight | 257.31 |
| Molecular formula | C13H11N3OS |
| CAS | 613262-61-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |