| Description | FX-06 (Fibrin-derived peptide Bβ15-42) is a peptide derived from the fibrin Bbeta chain. It interacts with VE-cadherin to inhibit leukocyte transmigration and initiate VE-cadherin-mediated signaling pathways. This compound has applications in researching ischemia/reperfusion injury and Dengue shock syndrome (DSS) [1] [2] [4]. |
| In vitro | FX-06 (50 μM, 3天) 抑制了转染IDH1 R132H [2] 的HEK-293T细胞中D2HG的产生。 |
| In vivo | FX06 (2.4 mg/kg, 静脉注射) 在大猪出血性休克及再灌注模型中显著改善肺部和循环功能[3]。FX06 (2.4 mg/kg, 腹腔注射, 每日两次) 提升登革热致休克小鼠的存活率，并减少毛细血管渗漏[4]。FX06 (3.6 mg/kg, 静脉注射) 通过促进上皮细胞增殖和组织修复，保护小鼠免受缺血/再灌注(I/R)引起的肾损伤[5]。 |
| Synonyms | Fibrin-derived peptide Bβ15-42 |
| molecular weight | 3039.41 |
| Molecular formula | C133H216N44O38 |
| CAS | 88650-17-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |