| Description | M617 acetate is a selective agonist of galanin receptor 1 (GAL1). M617 acetate acts through central GAL1, promotes GLUT4 expression, and enhances GLUT4 content in the cardiac muscle of type 2 diabetic rats. The Ki values are 0.23 and 5.71 nM for GAL1 and GAL2, respectively. |
| Target activity | GAL2:5.71 nM(Ki), GAL1:0.23 nM(Ki) |
| molecular weight | 2361.65 |
| Molecular formula | C112H161N29O28 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Fang P, et al. Central injection of GalR1 agonist M617 facilitates GLUT4 expression in cardiac muscle of type 2 diabetic rats. Exp Gerontol. 2015;65:85-89. 2. Lundström, L., et al. A Galanin Receptor Subtype 1 Specific Agonist. Int J Pept Res Ther 11, 17–27 (2005). |