| Description | LSN2463359 is a positive allosteric modulators of the mGlu5 receptor. |
| Synonyms | LSN-2463359, LSN 2463359 |
| molecular weight | 265.31 |
| Molecular formula | C16H15N3O |
| CAS | 1401031-52-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 112.5 mg/mL (424.0 mM), Sonication is recommended. |
| References | 1. Gilmour G, et al. In vitro characterisation of the novel positive allosteric modulators of the mGlu₅ receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat. Neuropharmacology. 2013 Jan;64:224-39. 2. Gastambide F, et al. The mGlu₅ positive allosteric modulator LSN2463359 differentially modulates motor, instrumental and cognitive effects of NMDA receptor antagonists in the rat. Neuropharmacology. 2013 Jan;64:240-7. 3. Gastambide F, et al. Selective remediation of reversal learning deficits in the neurodevelopmental MAM model of schizophrenia by a novel mGlu5 positive allosteric modulator. Neuropsychopharmacology. 2012 Mar;37(4):1057-66. |