| Description | Leteprinim (AIT 082 acid) is an hypoxanthine derivative that stimulates in vitro neurite outgrowth and the production of adenosine and neurotrophins from astrocytes. |
| In vitro | Leteprinim促进PC12细胞和神经元的神经突起生长，刺激星形细胞合成和/或释放神经营养因子，增强体内神经纤维再生，并在动物和人类中增强记忆力。Leteprinim还能抵抗体内外谷氨酸神经毒性，这导致了在急性中枢神经系统损伤动物模型中Leteprinim的成功测试[3]。 |
| In vivo | Leteprinim（每天60mg/kg；腹腔内注射，连续7天，自开腰果酰胺注射前20分钟开始）并未改变开腰果酰胺引起的癫痫发作，但像地西泮一样，减少了开腰果酰胺诱发的大鼠死亡率、GAD活性的降低以及海马神经元的损失[2]。 |
| Synonyms | AIT082 acid, AIT 082 acid, AIT-082 acid |
| molecular weight | 327.29 |
| Molecular formula | C15H13N5O4 |
| CAS | 138117-50-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 12.5 mg/mL (38.19 mM) |
| References | 1. Morrone CD, et al. Effects of Neurotrophic Support and Amyloid-Targeted Combined Therapy on Adult Hippocampal Neurogenesis in a Transgenic Model of Alzheimer's Disease. PLoS One. 2016 Oct 21;11(10):e0165393. 2. Di Iorio P, et al. AIT-082 is neuroprotective against kainate-induced neuronal injury in rats. Exp Neurol. 2001 Jun;169(2):392-9. 3. Rathbone MP, et al. AIT-082 as a potential neuroprotective and regenerative agent in stroke and central nervous system injury. Expert Opin Investig Drugs. 1999 Aug;8(8):1255-62. 4. Johnston TH, Brotchie JM. Drugs in development for Parkinson's disease. Curr Opin Investig Drugs. 2004 Jul;5(7):720-6. Review. |