| Description | Leptin (116-130),mouse(C64H109N19O24S),a peptide with the sequence Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser-NH2. Leptin is an adipocyte-derived hormone that acts as a major regulator for food intake and energy homeostasis. |
| In vitro | LEP-(116-130)（300 µM）无法抑制AP-OB的结合。此外，LEP-(116-130) 也不能在体外通过OB-Rb激活信号传导[1]。 |
| In vivo | LEP-(116-130)（1毫克，腹腔注射）在食物摄入量增加的情况下，与车辆注射对照小鼠相比，能显著降低体重增长速率。LEP-(116-130)通过降低约100 mg/dL血糖水平发挥作用。对野生型（+/+）C57BLKS/J-m小鼠进行LEP-(116-130)腹腔注射处理4天或7天，对其体温调节能力无影响[1]。 |
| molecular weight | 1560.73 |
| Molecular formula | C64H109N19O24S |
| CAS | 258276-95-8 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 10 mM |
| References | 1. Grasso P, et al. Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor. Diabetes. 1999 Nov;48(11):2204-9. |