| Description | LE 28 is a selective, activity-dependent probe for legumain that fluoresces exclusively upon binding to the active enzyme. It is applicable in research on cancers and inflammatory diseases [1]. |
| In vitro | LE 28 (0-5 μM, 1 h) 能够有效地通过荧光 SDS-PAGE 裂解和标记技术，在RAW细胞裂解物中检测legumain的存在 [1]。 |
| In vivo | LE 28（2 mg/kg，静脉注射）能够在小鼠肾脏中产生特异性信号[1]。同样，LE 28在HCT-116异种移植肿瘤模型中，注射后30分钟在肿瘤周边区域检测到该信号，并在7小时后观察到肿瘤与正常组织之间的信噪比达到峰值[1]。 |
| molecular weight | 1909.22 |
| Molecular formula | C102H111N10O21S3 |
| CAS | 1416080-97-1 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |