| Description | Bintrafusp alfa (M 7824), a pioneering bifunctional fusion protein, integrates the extracellular domain of TGF-βRII with a human IgG1 monoclonal antibody that inhibits the programmed cell death ligand. This compound is utilized in cancer research [1]. |
| In vitro | Bintrafusp alfa 能够提供持久的保护性免疫作用，能压抑调节性T细胞的功能，并显著提高CD8+ T细胞和自然杀伤细胞在肿瘤中的浸润，同时降低肿瘤微环境中由骨髓源性抑制细胞的浸润[1]。 |
| Synonyms | M7824, MSB0011359C |
| molecular weight | N/A |
| CAS | 1918149-01-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 years |