| Description | L-Methionine-DL-sulfoximine (MSO) inhibits glutamine synthetase and metabolically and morphologically primarily affects astroglia. L-Methionine-DL-sulfoximine can be used in convulsant studies. |
| Synonyms | MSX, MSO |
| molecular weight | 180.23 |
| Molecular formula | C5H12N2O3S |
| CAS | 15985-39-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: 50 mg/mL (277.42 mM), Sonication is recommended. DMSO: < 1.8 mg/mL (10 mM, insoluble or slightly soluble) |
| References | 1. Premakumar R, Sorger GJ, Gooden D. Repression of nitrate reductase in Neurospora studied by using L-methionine-DL-sulfoximine and glutamine auxotroph gln-1b. J Bacteriol. 1980;143(1):411-415. 2. Albrecht J, Norenberg MD. L-methionine-DL-sulfoximine induces massive efflux of glutamine from cortical astrocytes in primary culture. Eur J Pharmacol. 1990;182(3):587-589. |