| Description | L-AP3 is a potent antagonist of metabotropic glutamate receptor (mGluR), demonstrating inhibitory effects on D-phosphoserine and L-phosphoserine with IC50 values of 368 μM and 2087 μM, respectively. |
| In vitro | L-AP3 inhibits D-phosphoserine and L-phosphoserine with K i s of 151 μM and 845 μM, respectively[1]. L-AP3 has agonistic activity in enhancing phospholipase D activity and decreasing CAMP formation in rat hippocampus[1]. L-AP3 may have selectivity for Group II subtypes since it inhibits [ 3 H]glutamate binding to mGlu3, receptors (K i 125 μM)[1]. L-AP3 is a potent inhibitor of sodium-dependent L-[ 3 H]glutamate uptake in cerebellar and cortical synaptosomes (39 and 110 μM, respectively)[1]. |
| In vivo | L-AP3 has anticonvulsant activity in animals. L-AP3 blocks audiogenic seizures in DBA/2 mice[1]. |
| Synonyms | 3-Phosphono-L-alanine, L-AP3 |
| molecular weight | 169.073 |
| Molecular formula | C3H8NO5P |
| CAS | 23052-80-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. J E Hawkinson, et al. The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase. Eur J Pharmacol. 1996 Jun 27;307(2):219-25. |