| Description | L-708906 is the Human Immunodeficiency Virus Type 1 inhibitor. |
| Synonyms | L708906, ARRY 142886, ARRY-142886, ARRY142886, L 708906 |
| molecular weight | 404.41 |
| Molecular formula | C24H20O6 |
| CAS | 251963-74-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Beare KD, Coster MJ, Rutledge PJ. Diketoacid inhibitors of HIV-1 integrase: from L-708,906 to raltegravir and beyond. Curr Med Chem. 2012;19(8):1177-92. Review. PubMed PMID: 22214459. 2. Barreca ML, Iraci N, De Luca L, Chimirri A. Induced-fit docking approach provides insight into the binding mode and mechanism of action of HIV-1 integrase inhibitors. ChemMedChem. 2009 Sep;4(9):1446-56. doi: 10.1002/cmdc.200900166. PubMed PMID: 19544345. 3. Chi G, Nair V, Semenova E, Pommier Y. A novel diketo phosphonic acid that exhibits specific, strand-transfer inhibition of HIV integrase and anti-HIV activity. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1266-9. Epub 2006 Dec 15. PubMed PMID: 17188872; PubMed Central PMCID: PMC1839884. 4. Johnson AA, Marchand C, Pommier Y. HIV-1 integrase inhibitors: a decade of research and two drugs in clinical trial. Curr Top Med Chem. 2004;4(10):1059-77. Review. PubMed PMID: 15193139. |