| Description | CYP121A1-IN-1 is a potent inhibitor of CYP121A1, demonstrating favorable activity against Mycobacterium tuberculosis (H37Rv MIC 90 ~6.25 μM, ~2.2 μg/mL). It significantly reduces mycocyclosin production by blocking the CYP121A1-mediated conversion of cyclo(l-tyrosyl-l-tyrosyl) to mycocyclosin [1]. |
| In vitro | CYP121A1-IN-1 (compound 61) (0.78-400 μM; one week for c7H9 and 7H9-Low BSA media or two weeks for MMM-Ch medium) has favorable activity against Mtb strain H37Rv (MIC 90 ～6.25 μM, ～2.2 μg/mL) [1]. |
| molecular weight | 356.42 |
| Molecular formula | C22H20N4O |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |