| Description | L-701252, a potent glycine site NMDA receptor antagonist, exhibits an inhibition concentration (IC50) of 420 nM. Additionally, it offers marginal neuroprotection against global cerebral ischemia. |
| In vivo | L-701252（50 mg/kg；i.p.）提供了一定程度的非显著保护[1]。 |
| Synonyms | L-701,252 |
| molecular weight | 263.68 |
| Molecular formula | C13H10ClNO3 |
| CAS | 151057-13-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 1 mg/mL, Sonication is recommended. |
| References | 1. Stone TW. Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. Trends Pharmacol Sci. 2000;21(4):149-154. 2. Widdowson PS, et al. Failure of glycine site NMDA receptor antagonists to protect against L-2-chloropropionic acid-induced neurotoxicity highlights the uniqueness of cerebellar NMDA receptors. Brain Res. 1996;738(2):236-242. |