| Description | Co 101244 hydrochloride (4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride) is an NR2B-containing NMDA receptor antagonist. |
| In vitro | Co 101244 显著增强了神经保护作用，并有效降低了 NMDA 引发的 Ca2+ 浓度升高[1]。 |
| In vivo | 给予1 mg/kg 皮下注射Co 101244展示了抗运动障碍效果，减少了67%的症状同时保留了左旋多巴的运动益处[1]。 |
| Synonyms | Co 101244盐酸盐, 4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride |
| molecular weight | 377.9 |
| Molecular formula | C21H28ClNO3 |
| CAS | 193356-17-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: < 35 mg/mL (92.62 mM) DMSO: 50 mg/mL (132.31 mM) |
| References | 1. Ruslan I Stanika, et al. Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9854-9. |