| Description | L 152804 is a specific antagonist of the neuropeptide Y Y5 receptor and modulates food intake and energy expenditure thus causing weight loss in diet-induced obese mice. |
| In vitro | L 152804 displays Ki of 26 nM for human neuropeptide Y Y5 with > 300-fold selectivity over hY1, hY2, and hY4 receptors[1]. |
| Target activity | NPY5R:26 nM(ki) |
| molecular weight | 366.45 |
| Molecular formula | C23H26O4 |
| CAS | 6508-43-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 112.5 mg/mL (307.0 mM) |
| References | 1. Kanatani A, et al. L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochem Biophys Res Commun. 2000 May 27;272(1):169-73. 2. Mashiko S, et al. A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Mol Pharmacol. 2007 Feb;71(2):602-8. Epub 2006 Nov 14. |