| Description | [D-Trp34]-Neuropeptide Y Acetate is a potent and selective agonist of neuropeptide Y (NPY) Y5 receptor. [D-Trp34]-Neuropeptide acetate Y is a significantly less potent agonist at the NPY Y1, Y2, Y4, and y6 receptors. [D-Trp34]-Neuropeptide Y Acetate markedly increases food intake in rats. |
| In vitro | [D-Trp34]-Neuropeptide Y Acetate 在 CHO 细胞中对 hY1、hY2、hY4、hY5、rY1、rY2、rY4、rY5 的 pKi 值分别为 6.49、5.43、7.08、7.53、6.55、5.95、6.85、7.41；在 CHO 细胞中对 rY1、rY2 以及在 HEK-293 细胞中对 rY4、rY5 的 pEC50 值分别为 6.44、<6、6.28、7.82[1]。 |
| In vivo | [D-Trp34]-Neuropeptide Y Acetate（0、8 和 16 μg/大鼠；I.C.V）在雄性 Zucker 大鼠中注射 16 μg 剂量 1 小时后，对瘦大鼠和肥胖大鼠的食物摄入量具有相同程度的刺激作用[2 ]。 |
| Synonyms | [D-Trp34]-Neuropeptide Y Acetate (153549-84-9 Free base) |
| molecular weight | 4371.78 |
| Molecular formula | C198H293N55O58 |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. E M Parker, et al. [D-Trp(34)] neuropeptide Y is a potent and selective neuropeptide Y Y(5) receptor agonist with dramatic effects on food intake. Peptides. 2000 Mar;21(3):393-9. 2. Bernard Beck, et al. Responsiveness of obese Zucker rats to [D-Trp34]-NPY supports the targeting of Y5 receptor for obesity treatment. Nutr Neurosci. Oct-Dec 2007;10(5-6):211-4. |