| Description | KGP94 is a potent, selective, and competitive inhibitor of the lysosomal endopeptidase enzyme. |
| In vitro | 新型的卡特普酶L/K抑制剂KGP94能够在体外抑制M2型巨噬细胞的侵袭，并降低巨噬细胞刺激下的4T1小鼠乳腺癌细胞侵袭。KGP94处理还降低了几种与M2相关的标志物的表达，表明卡特普酶L的活性可能对IL-4驱动的M0到M2的分化至关重要[1]。 |
| Synonyms | KGP-94, KGP 94 |
| molecular weight | 350.23 |
| Molecular formula | C14H12BrN3OS |
| CAS | 1131456-28-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 60 mg/ml (171.32 mM) |
| References | 1. Dykes SS, Fasanya HO, Siemann DW. Cathepsin L secretion by host and neoplastic cells potentiates invasion. Oncotarget. 2019 Sep 17;10(53):5560-5568. 2. Sudhan DR, et al. Cathepsin L in tumor angiogenesis and its therapeutic intervention by the small molecule inhibitor KGP94. Clin Exp Metastasis. 2016 Jun;33(5):461-73. 3. Sudhan DR, et al. Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model. Int J Cancer. 2016 Jun 1;138(11):2665-77. 4. Sudhan DR, Siemann DW. Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells. Clin Exp Metastasis. 2013 Oct;30(7):891-902. |