Kaempferol 3-O-(6''-galloyl)-beta-D-glucopyranoside Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	Kaempferol 3-O-(6''-galloyl)-beta-D-glucopyranoside is a glucopyranoside that inhibits HIV-2 RNase H with an IC50 of 5.19 μM.
In vitro	Kaempferol 3-O-(6″- galloyl)-β-D-glucopyranoside（化合物3；KGG）(12、25、50 μM) 抑制了RAW 264.7细胞中NLRP3蛋白的表达。使用这些分离的化合物3能够显著且依赖浓度地抑制RAW 264.7细胞中IL-1β蛋白的表达。[2] Kaempferol 3-O-(6″- galloyl)-β-D-glucopyranoside（化合物1）在0.46 mM的IC50值上展示了最强的抑制效力。酶动力学稳态研究揭示，1对ATP表现出了竞争性抑制。[3]
Target activity	α-glucosidase:5.60 ± 1.57 μM, HIV-2:5.19 μM
molecular weight	600.48
Molecular formula	C28H24O15
CAS	56317-05-6
Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
References	1. Lima R C L, et al. Brazilian insulin plant as a bifunctional food: Dual high-resolution PTP1B and α-glucosidase inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of antidiabetic compounds in Myrcia rubella Cambess. Journal of Functional Foods. 2018; 45:444-451. 2. Kim EB, et al. Antiacne and Anti-Inflammatory Effects of Phenolic Compounds from Quercus acutissima Carruth. Leaves. Evid Based Complement Alternat Med. 2022;2022:9078475. 3. Lee YE, et al. Flavonoids from Woodfordia fruticosa as potential SmltD inhibitors in the alternative biosynthetic pathway of peptidoglycan. Bioorg Med Chem Lett. 2021;36:127787.

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