| Description | JNJ-40411813 (ADX-71149) (ADX-71149) is a new positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R, EC50: 147 nM). |
| Target activity | mGlu2 receptor:147 nM (EC50) |
| Synonyms | ADX-71149 |
| molecular weight | 344.88 |
| Molecular formula | C20H25ClN2O |
| CAS | 1127498-03-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 24 mg/mL (69.59 mM), Sonication is recommended. |
| References | 1. Cid JM, et al. Discovery of 1-Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor. J Med Chem. 2014 Aug 14;57(15):6495-512. |