| Description | JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1. |
| In vitro | JH-X-119-01 exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88.?Cotreatment of JH-X-119-01 with the BTK inhibitor ibrutinib resulted in synergistic killing effects in these systems. |
| Target activity | IRAK1:9 nM |
| molecular weight | 452.46 |
| Molecular formula | C25H20N6O3 |
| CAS | 2227368-54-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 12 mg/ml (26.52 mM), Sonication is recommended. |
| References | 1. John M Hatcher, et al.ACS Med Chem Lett.2020 Oct 9;11(11):2238-2243. |