| Description | Isorhamnetin-3-O-glucoside (Isorhamnetin-3-O-beta-D-Glucoside) inhibits the activity of alpha-glucosidase from rat intestine; it exhibits a potent rat lens aldose reductase (RLAR) inhibition in vitro, its IC(50) being 1.4 microM and has inhibitory effects of sorbitol accumulation, suggests that it is a leading compound for further study as a new drug for the prevention and/or treatment of diabetes and its complications. |
| In vitro | Salicornia herbacea（Chenopodiaceae）中化合物对大鼠晶状体醛糖还原酶（RLAR）和链脲佐菌素诱导的糖尿病大鼠组织中山梨醇积累的抑制效果进行了研究。通过对S. herbacea的甲醇提取物不同部分对体外RLAR影响的测试中，发现乙酸乙酯（EtOAc）分部显示出强大的RLAR抑制作用（IC(50)=0.75 microg/ml），并从中分离出一种活性原理作为强效AR抑制剂，其化学结构通过光谱分析被确定为Isorhamnetin-3-O-beta-D-Glucoside（1）。化合物1对RLAR展现出强大的体外抑制作用，其IC(50)为1.4 microM。口服给予化合物1（25 mg/kg）于STZ诱导的糖尿病大鼠，不仅显著抑制了血清葡萄糖浓度，也抑制了晶状体、红细胞（RBC）和坐骨神经中的山梨醇积累。这些结果表明，来自S. herbacea的化合物1是作为预防和/或治疗糖尿病及其并发症新药进一步研究的先导化合物。 |
| Synonyms | Isorhamnetin-3-O-beta-D-Glucoside, 异鼠李素-3-O-葡萄糖苷 |
| molecular weight | 478.4 |
| Molecular formula | C22H22O12 |
| CAS | 5041-82-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 250 mg/mL (522.58 mM), Sonication is recommended. |
| References | 1. Inhibitory effects of isorhamnetin-3-O-beta-D-glucoside from Salicornia herbacea on rat lens aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues. Biol Pharm Bull. 2005 May;28(5):916-8. 2. A review of chemistry and biological activities of the genus Aerva--a desert plant. Acta Pol Pharm. 2012 Mar-Apr;69(2):171-7. 3. Antioxidant constituents in the dayflower (Commelina communis L.) and their alpha-glucosidase-inhibitory activity. J Nat Med. 2008 Jul;62(3):349-53. |