| Description | ES9-17, an analog of ES9 (endosidin9), is an inhibitor of clathrin-mediated endocytosis (CME). ES9-17 inhibits the uptake of FM4-64 and transferrin. ES9-17 inhibits root growth of Arabidopsis seedings. |
| In vitro | ES9-17 (0-100 μM; 30分钟) 抑制亲脂性苯乙烯基内吞示踪剂 (FM4-64) 的吸收，EC50 为 13 μM。ES9-17（30 μM; 30分钟）不消耗拟南芥细胞的 ATP。ES9-17（30 μM; 30分钟）减少了HeLa细胞对转铁蛋白的摄取[1]。ES9-17 针对CHC，调节内膜运输途径，且不引起胞浆酸化[2]。 |
| molecular weight | 318.21 |
| Molecular formula | C10H8BrNO2S2 |
| CAS | 55854-43-8 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 25 mg/mL (78.57 mM) |
| References | 1. Dejonghe W, et al. Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nat Chem Biol. 2019 Jun;15(6):641-649. 2. Huang L, et al. Progress in using chemical biology as a tool to uncover novel regulators of plant endomembrane trafficking. Curr Opin Plant Biol. 2019 Dec;52:106-113. |