| Description | 1. ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponectin production. 2. Isoginkgetin has anti-tumor activity, the mechanistic basis is splicing inhibition , thus, pre-mRNA splicing inhibitors may represent a novel avenue for development of new anti-cancer agents.3. Isoginkgetin can inhibit tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. 4. Isoginkgetin (0.3mg/kg ip for 3d) can reduce the level of O2·- in plasma and erythroeyte and sometimes increase the activity of SOD in anoxic rats, the action being stronger than aspirin. |
| Synonyms | 异银杏素, 4',4'''-Dimethylamentoflavone, 异银杏双黄酮 |
| molecular weight | 566.51 |
| Molecular formula | C32H22O10 |
| CAS | 548-19-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 83.3 mg/mL (147.04 mM) |
| References | 1. Suhua P . Effect of Isoginkgetin on Scavenge of Oxygen Free Radical in Anoxic Rats[J]. Traditional Chinese Drug Research & Clinical Pharmacology, 1993. |
| Citations | 1. Theerawatanasirikul S, Thangthamniyom N, Kuo C J, et al. Natural Phytochemicals, Luteolin and Isoginkgetin, Inhibit 3C Protease and Infection of FMDV, In Silico and In Vitro. Viruses. 2021, 13(11): 2118. 2. Xiao Y, Cai G P, Feng X, et al.Splicing factor YBX1 regulates bone marrow stromal cell fate during aging.The EMBO Journal.2023: e111762. |