| Description | Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) is a T-cell modulator, a bile acid metabolite with anti-inflammatory activity that is associated with human immune homeostasis. |
| In vitro | Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) (20 μM) 可以将Th17细胞的分化减少约50%，而不影响RORγt的表达。[1] Isoallolithocholic acid对T细胞分化成Th1或Th2细胞没有影响，且其对Tregs的调节作用具有细胞类型特异性。[1] Isoallolithocholic acid对于FoxP3表达的增强依赖于mitoROS。[1] |
| In vivo | Isoallolithocholic acid（0.03%；饮食中；7天；带有分段丝状细菌（SFB）的Jax-B6小鼠）在稳定状态及单独使用抗CD3治疗后，均未能增加Treg细胞比例。与对照饮食相比，与0.3%（w/w）3-氧代-石胆酸（3-oxoLCA）结合使用的抗CD3治疗显著增强了小鼠中的Treg细胞群。减少了CD45.1+ T效应细胞的数量。在B6小鼠中增强Treg细胞。[1] |
| Synonyms | Alloisolithocholic Acid, AILCA, 3β-Hydroxy-5α-cholanic acid |
| molecular weight | 376.57 |
| Molecular formula | C24H40O3 |
| CAS | 2276-93-9 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMF: 1 mg/mL DMF:PBS (pH 7.2) (1:3): 0.25 mg/mL |
| References | 1. Bukiya, A.N., McMillan, J., Parrill, A.L., et al.Structural determinants of monohydroxylated bile acids to activate β1 subunit-containing BK channelsJ. Lipid Res.49(11)2441-2451(2008) 2. Vonk, R.J., Tuchweber, B., MassÉ, D., et al.Intrahepatic cholestasis induced by allo monohydroxy bile acid in ratsGastroenterology80(2)242-249(1981) |