| Description | Ipamorelin 2 Pivalic acid (NNC-26-0161) is a growth-hormone-releasing peptide, induces longitudinal bone growth in rats. |
| In vitro | 在体外实验中，Ipamorelin从初级大鼠垂体细胞释放生长激素（GH），其功效和效力与GHRP-6相似，EC50值为1.3±0.4nmol/l，最大效应（Emax）为85±5%，相比之下GHRP-6的EC50值为2.2±0.3nmol/l，最大效应为100%。通过使用GHRP和生长激素释放激素（GHRH）拮抗剂进行药理学分析清楚地证明，Ipamorelin像GHRP-6一样，通过一个类GHRP的受体来刺激GH的释放[1]。 |
| In vivo | 在戊巴比妥麻醉的大鼠中，ipamorelin释放GH的效力和效率与GHRP-6相当（ED50 = 80+/-42 nmol/kg，Emax = 1545+/-250 ng GH/ml对比115+/-36 nmol/kg和1167+/-120 ng GH/ml）。在清醒的猪中，ipamorelin释放GH的ED50 = 2.3+/-0.03 nmol/kg，Emax = 65+/-0.2 ng GH/ml血浆。这同样与GHRP-6非常相似（ED50 = 3.9+/-1.4 nmol/kg，Emax = 74+/-7 ng GH/ml血浆）[1]。 |
| Synonyms | NNC-26-0161 |
| molecular weight | 916.12 |
| Molecular formula | C38H49N9O5.2C5H10O2 |
| Storage | keep away from moisture|Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mM |
| References | 1. Raun K , Hansen B , Johansen N , et al. Ipamorelin, the first selective growth hormone secretagogue[J]. European Journal of Endocrinology, 1998, 139(5):552-561. 2. Johansen P B , Nowak J , Skj?Rb?K C , et al. Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats[J]. Growth Hormone & Igf Research, 1999, 9(2):0-113. |