| Description | Iopamidol (SQ-13396) is a benzenedicarboxamide compound. It has a role as a radioopaque medium, an environmental contaminant and a xenobiotic. |
| In vitro | Iopamidol significantly decreases the rate of atrial contraction to a greater extent than either formulation of iodixanol. Iopamidol decreases papillary muscle force development more than the sodium formulation of iodixanol[3]. |
| In vivo | Iopamidol increases systolic blood pressure (SBP), mean arterial pressure (MAP), and peak left ventricular pressure (LVP). Iopamidol increases LVP and LV end diastolic pressure to a greater extent than the cationic formulation of iodixanol. Thus iopamidol affects cardiovascular parameters more than iodixanol[3]. |
| Cell experiments | Chondrocytes are plated on 96 well plates at a density of 1 x 106 cells/cm2 . After overnight incubation in standard tissue culture conditions, contrast agents (including iopamidol) are introduced to wells in varying concentrations. Following 16 hour incubation with PBS and contrast agents, chondrocyte viability is assessed using the Live/Dead stain kit and quantified using the CellTiter-Glo Luminescent Cell Viability Assay. (Only for Reference) |
| Synonyms | SQ-13396, Niopam, Iopamiron, Iopamiro, 碘帕醇, B-15000, Isovue |
| molecular weight | 777.09 |
| Molecular formula | C17H22I3N3O8 |
| CAS | 60166-93-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | Ethanol: < 1 mg/mL (insoluble or slightly soluble) H2O: 92 mg/mL (118.4 mM) DMSO: 93 mg/mL (119.7 mM) |
| References | 1. Longo DL, et al. Magn Reson Med. 2011, 65(1):202-11. 2. Doan R, et al. 55th Annual Meeting of the Orthopaedic Research Society. Poster No.2166 3. Dundore RL, et al. Invest Radiol. 1991, 26(8):715-21. 4. Xu S, Wang L, Zhao L. Clinical application value of brain CT perfusion imaging in the treatment of acute ischemic stroke thrombolytic therapy[J]. Experimental and therapeutic medicine. 2019 May;17(5):3971-3976. |
| Citations | 1. Xu S, Wang L, Zhao L. Clinical application value of brain CT perfusion imaging in the treatment of acute ischemic stroke thrombolytic therapy. Experimental and Therapeutic Medicine. 2019 May;17(5):3971-3976 |