| Description | Iobenguane sulfate (MIBG sulfate) is a high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation). Radioiodinated Iobenguane sulfate is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. |
| In vitro | Iobenguane sulfate 是一种有效的土耳其和人类红细胞膜内源性单(ADP-核糖)转移酶的效应器。Iobenguane sulfate (2-20 μg/ml；72小时) 在一系列人类和小鼠的白血病、黑色素瘤、纤维肉瘤和神经母细胞瘤细胞系中抑制细胞生长。 |
| In vivo | Iobenguane sulfate（20 mg/kg；腹腔注射；第3至第6天每日一次）显示出抗肿瘤活性。Iobenguane sulfate对雄性AF（N1Ell5）菌株小鼠的毒性进行了测试，方法是连续5天每天注射一次。当剂量达到50 mg/kg时，所有动物在1-4次剂量后死亡，而在44 mg/kg的计划下有4/16的动物死亡。按照NIH新药测试协议，接种N1E115神经母细胞瘤并用Iobenguane sulfate（40 mg/kg）治疗的雄性AF菌株小鼠，经过连续9天的注射后，生存时间显著延长，但未观察到治愈情况。 |
| Synonyms | MIBG sulfate |
| molecular weight | 324.12 |
| Molecular formula | C8H10IN3.1/2H2O4S |
| CAS | 87862-25-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 100 mg/mL (308.52 mM), Sonication is recommended. |
| References | 1. Loesberg C, et al. Meta-iodobenzylguanidine (MIBG), a novel high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation). Biochim Biophys Acta. 1990 Jan 19;1037(1):92-9. |