| Description | COH34 (1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol) is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors. |
| In vitro | COH34高效抑制了对PARP抑制剂具有抗性的癌细胞[1]。 |
| In vivo | COH34在移植瘤小鼠癌症模型中表现出抗肿瘤活性[1]。 |
| Target activity | PARG:0.37 nM |
| Synonyms | 1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol |
| molecular weight | 293.38 |
| Molecular formula | C18H15NOS |
| CAS | 906439-72-3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 15 mg/mL (51.1 mM), Sonication is recommended. |
| References | 1. Chen SH, et al. Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Sci Adv. 2019 Apr 10;5(4):eaav4340. |