| Description | IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L. |
| Cell experiments | ChIP assay on the HES1 promoter using the indicated antibodies following treatment of OE33 and 786-0 cells with DAPT (15 μM), IMR-1 (25 μM), or vehicle (DMSO) using GAPDH as loading control. (Only for Reference) |
| Target activity | Notch:6 μMol/L |
| molecular weight | 353.41 |
| Molecular formula | C15H15NO5S2 |
| CAS | 310456-65-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 60 mg/mL (169.77 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Astudillo L et al. Cancer Res. 2016 Jun 15;76(12):3593-603. |