| Description | Imazamox ((±)-Imazamox) is a systemic herbicide with high selectivity, high activity, safety and broadspectrum activity. Imazamox inhibits the production of acetolactate synthase (ALS) in plants, which would then inhibit plant growth and ultimately lead to plant death. |
| In vitro | Imazamox在土壤中的半衰期为1至3个月，表现出低哺乳动物毒性[1]。Imazamox主要在V. sativa中积累，其浓度是P.vulgaris检测到的六倍[3]。 |
| In vivo | Imazamox处理减小了β-岛细胞的大小，并且还引起血清中的葡萄糖和钙的增加。Imazamox（12-36mg/kg; 腹腔注射; 24-72小时; 雄性Sprague-Dawley大鼠）处理在Sprague Dawley大鼠的肝脏和胰腺中引起了毒性效应。在两个最高剂量的肝细胞中，检测到坏死和退行性变化[4]。 |
| Synonyms | CL29926, 甲氧咪草烟, (±)-Imazamox |
| molecular weight | 305.33 |
| Molecular formula | C15H19N3O4 |
| CAS | 114311-32-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 45 mg/mL (147.38 mM), Sonication is recommended. |
| References | 1. Wei J et al. Enantioselective Phytotoxicity of Imazamox Against Maize Seedlings. Bull Environ Contam Toxicol. 2016 Feb;96(2):242-7. 2. García-Garijo A, et al. Metabolic responses in root nodules of Phaseolus vulgaris and Vicia sativa exposed to the imazamox herbicide. Pestic Biochem Physiol. 2014 May;111:19-23. 3. Imazamox Chemical Fact Sheet. Wisconsin Department of Natural Resources. DNR PUB-WT-974 2012. 4. Sevim Ç, et al. An imazamox-based herbicide causes apoptotic changes in rat liver and pancreas. Toxicol Rep. 2018 Nov 19;6:42-50. |