| Description | IGS-1.76 exhibits pronounced affinity towards hNCS-1 and effectively modulates the interaction between hNCS-1 and Ric8a. Moreover, IGS-1.76 proficiently inhibits the complex formed by human NCS-1 and Ric8a. |
| In vitro | IGS-1.76能高效抑制人类的NCS-1/Ric8a复合体，并具有提高的结合效能。 |
| Target activity | TRPC3:0.49 uM |
| molecular weight | 358.46 |
| Molecular formula | C22H18N2OS |
| CAS | 313480-47-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 22.5 mg/mL (62.77 mM) |
| References | 1. Carlos Roca, et al. Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators. J Med Chem. 2018 Jul 26;61(14):5910-5921. |