| Description | Hypromellose (HPMC) is a water-soluble hydrophilic, non-ionic cellulose ether. |
| In vitro | Hypromellose（羟丙基甲基纤维素）多年来被应用于缓释化合物制品中。这类聚合物接触水时会吸水膨胀，形成粘稠的凝胶屏障，包裹并存在于片剂内外，用于矩阵片剂中。影响化合物释放速率的Hypromellose特性包括水分进入干燥聚合物的扩散率、Hypromellose水化与凝胶形成的速率、水化后Hypromellose的粘度以及Hypromellose凝胶侵蚀的速率[2]。Hypromellose提供了一种控制释放的方式，有效地延长化合物释放的持续时间，从而延长其治疗效果[1]。 |
| In vivo | 使用2%Hypromellose进行泪点封堵是一种成本低廉且安全的干眼症辅助治療方法。荧光素和罗丹明染色测试显示，使用Hypromellose封堵后，干眼症症状明显减轻[3]。此外，Hypromellose在提高高脂饮食小鼠的血糖代谢和抑制氧化压力方面表现出有效性。其抗高血糖和抗氧化作用部分归因于调节肝脏糖调节酶活性及激活肝脏和红细胞的抗氧化酶[4]。 |
| Synonyms | Celacol HPM 5000, HPMC, 羟丙甲纤维素, (Hydroxypropyl)methyl cellulose |
| molecular weight | 1261.44 |
| Molecular formula | C56H108O30 |
| CAS | 9004-65-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 12.61 mg/mL (10 mM), Sonication is recommended. H2O: 9 mg/mL, Sonication is recommended. |
| References | 1. Li CL, et al. The use of hypromellose in oral drug delivery. J Pharm Pharmacol. 2005 May;57(5):533-46. 2. Braund R, et al. Hypromellose films for the delivery of growth factors for wound healing. 3. Capita L, et al. Prospective evaluation of hypromellose 2% for punctal occlusion in patients with dry eye. Cornea. 2015 Feb;34(2):188-92. 4. Ban SJ, et al. Antihyperglycemic and antioxidative effects of Hydroxyethyl Methylcellulose (HEMC) and Hydroxypropyl Methylcellulose (HPMC) in mice fed with a high fat diet. Int J Mol Sci. 2012;13(3):3738-50. |