| Description | HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model |
| In vitro | HS-1793被发现能在蛋白水平上抑制低氧(1.0%氧气)诱导的HIF-1α表达，并且其抑制效果比resveratrol在MCF-7和MDA-MB-231乳腺癌细胞中更为强大。此外，HS-1793降低了血管内皮生长因子(VEGF)的分泌和mRNA表达，VEGF是HIF-1驱动的血管生成的关键媒介，同时并未影响细胞活力。 |
| In vivo | HS-1793显著抑制了乳腺癌肿瘤异种移植物的生长，且未观察到明显的毒性。此外，肿瘤组织中Ki-67（一种增殖指数标志物）和CD31（微血管密度的生物标记）的表达均有所下降。经HS-1793处理的异种移植肿瘤中，HIF-1和VEGF的表达也被下调。这些体内结果强化了与Resveratrol相比，HS-1793在抗癌活性上的改进。总体而言，本研究表明，合成的Resveratrol类似物HS-1793是一种强大的抗肿瘤剂，它通过调控HIF-1来抑制肿瘤生长，并展现出对实体癌症的显著治疗潜力。 |
| molecular weight | 252.26 |
| Molecular formula | C16H12O3 |
| CAS | 927885-00-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 22.5 mg/mL (89.19 mM) |
| References | 1. D Kim, Sung B , Kim J A , et al. HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model[J]. International Journal of Oncology, 2017. |
| Citations | 1. Xu Q, Fu Q, Li Z, et al. The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice. Nature Metabolism. 2021: 1-21. |