| Description | Hispolon is a polyphenol. Hispolon can be isolated from Phellinus linteus. Hispolon exhibits anticancer, antidiabetic, antiviral, hepatoprotective, antioxidant, and anti-inflammatory activities. |
| In vitro | Hispolon（25和50 μM, 2-8小时）降低了与G1-S过渡有关的蛋白cyclin D4的表达，但提高了CDK抑制剂p21的表达。Hispolon（25和50 μM, 24, 48小时）在U87MG细胞中诱导G2/M细胞周期阻滞和凋亡。Hispolon（25和50 μM, 24-72小时）抑制了U87MG细胞的活力。Hispolon（25和50 μM, 24小时）抑制了U87MG细胞的迁移[2]。 |
| In vivo | Hispolon（5和10 mg/kg，皮下注射）能够减缓DBTRG移植小鼠[3]中的肿瘤生长。Hispolon（2.5-10 mg/kg，腹腔注射）可缓解小鼠[4]中LPS诱导的急性肺损伤。 |
| molecular weight | 220.22 |
| Molecular formula | C12H12O4 |
| CAS | 173933-40-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 112.5 mg/mL (510.8 mM), Sonication and heating to 70℃ are recommended. |
| References | 1. Sarfraz A, et al. Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways. Environ Res. 2020 Nov;190:110017. 2. Arcella A, et al. Effects of hispolon on glioblastoma cell growth. Environ Toxicol. 2017 Sep;32(9):2113-2123. 3. Liao KF, et al. Hispolon Induces Apoptosis, Suppresses Migration and Invasion of Glioblastoma Cells and Inhibits GBM Xenograft Tumor Growth In Vivo. Molecules. 2021 Jul 26;26(15):4497. 4. Huang CY, et al. Attenuation of Lipopolysaccharide-Induced Acute Lung Injury by Hispolon in Mice, Through Regulating the TLR4/PI3K/Akt/mTOR and Keap1/Nrf2/HO-1 Pathways, and Suppressing Oxidative Stress-Mediated ER Stress-Induced Apoptosis and Autophagy. Nutrients. 2020 Jun 10;12(6):1742. |