| Description | DNA2 inhibitor C5 is a promising lead compound to develop sensitizers for cancer chemotherapeutics that cause replication stress and it also is a competitive and specific inhibitor of DNA2 nuclease activity (IC50: 20 μM). DNA2 inhibitor C5 inhibits nuclease, DNA dependent ATPase, helicase, and DNA binding activities of DNA2. |
| Target activity | DNA2 nuclease:20 μM |
| molecular weight | 234.16 |
| Molecular formula | C10H6N2O5 |
| CAS | 35973-25-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 31.25 mg/mL (133.45 mM), Sonication is recommended. |
| References | 1. Binghui Shen, et al. Dna2 inhibitors for cancer treatment. US20170226063A1. |