| Description | Hispidin is a polyphenol originally, including antioxidant, anti-inflammatory, and cytoprotective properties |
| In vitro | Hispidin from P. linteus exhibited quenching effects against DPPH radicals, superoxide radicals, and hydrogen peroxide in a dose-dependent manner. Intracellular reactive oxygen species scavenging activity of hispidin was approximately 55% at a concentration of 30 μM. In addition, hispidin was shown to inhibit hydrogen peroxide-induced apoptosis and increased insulin secretion in hydrogen peroxide-treated cells. These combined results indicate that hispidin may act as an antidiabetic and that this property occurs through preventing β-cells from the toxic action of reactive oxygen species in diabetes[1].Hispidin inhibits protein kinase C β (PKCβ ; IC50 = 2 μM) with no activity against alkaline phosphatase[2] |
| Synonyms | 6-[(1E)-2-(3,4-二羟基苯基)乙烯基]-4-羟基-2H-吡喃-2-酮 |
| molecular weight | 246.22 |
| Molecular formula | C13H10O5 |
| CAS | 555-55-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 22.5 mg/mL (91.38 mM) |
| References | 1. Jang J S , Lee J S , Lee J H , et al. Hispidin produced from Phellinus linteus protects pancreatic β-cells from damage by hydrogen peroxide[J]. Archives of Pharmacal Research, 2010, 33(6):p.853-861. 2. Gonindard C , Bergonzi C , Denier C , et al. Synthetic hispidin, a PKC inhibitor, is more cytotoxic toward cancer cells than normal cells in vitro[J]. Cell Biology and Toxicology, 1997, 13(3):141-153. |