| Description | HexylHIBO is a type I mGluR antagonist that inhibits mGlu1a and mGlu5a, with Kb values of 140 and 110 μM, respectively.HexylHIBO decreases sEPSC in rats. |
| Target activity | mGlu5a:110 μM(Kb), mGlu1a:140 μM(Kb) |
| molecular weight | 256.3 |
| Molecular formula | C12H20N2O4 |
| CAS | 334887-43-3 |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | 1eq. NaOH: 18.0 mg/mL (70.2 mM) |
| References | 1. Hengen P. Purification of His-Tag fusion proteins from Escherichia coli. Trends Biochem Sci. 1995;20(7):285-286. 2. Madsen U, et al. Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors. J Med Chem. 2001;44(7):1051-1059. 3. Bandrowski AE, et al. Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex. J Neurophysiol. 2003;89(3):1308-1316. |