| Description | A-794282 is a selective and potent mGlu1 receptor antagonist with analgesic activity and may be useful in the study of neurologic disorders. |
| In vivo | 方法：在本研究中，在大鼠皮肤切口诱导的术后疼痛模型中评估了强效和选择性 mGlu1 受体拮抗剂 A-794282（腹腔注射）的作用。手术后 2 小时检查术后疼痛，使用受伤和未受伤爪子之间的承重差异作为自发性疼痛的衡量标准。结果：在该模型中，A-794282、诱导自发性术后疼痛行为显着减弱，ED50 分别为 50 μmol/kg 。[2] |
| Synonyms | A 794282, A794282 |
| molecular weight | 350.44 |
| Molecular formula | C19H18N4OS |
| CAS | 869802-44-8 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Yang YL,et al. [Research progress of selective mGluR1 antagonists]. Yao Xue Xue Bao. 2011 Oct;46(10):1167-72. Review. Chinese. 2. Zhu CZ,et al. Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats. Eur J Pharmacol. 2008 Feb 12;580(3):314-21. 3. Zheng GZ,et al. Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists. J Med Chem. 2005 Nov 17;48(23):7374-88. |