| Description | H-Leu-Leu-OMe . HBr is a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes. H-Leu-Leu-OMe . HBr induces endolysosomal pathway stress and selectively eliminates lymphocytes with cytotoxic potential. |
| In vitro | H-Leu-Leu-OMe . HBr（10-250 μM；15分钟）通过CD4-淋巴细胞转化为CCI3COOH-不溶性产物[1]。同样，H-Leu-Leu-OMe . HBr（1 mM；0.5-2小时）在MEFs和A549细胞中增强LRRK2介导的Rab10和Rab12磷酸化[2]。 |
| Synonyms | H-Leu-Leu-OMe . HBr (16689-14-8 Free base) |
| molecular weight | 399.32 |
| Molecular formula | C15H31BrN2O5 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 45 mg/mL (112.69 mM) |
| References | 1. Thiele DL, et, al. Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells. Proc Natl Acad Sci U S A. 1990 Jan;87(1):83-7. 2. Kalogeropulou AF, et, al. Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity. Biochem J. 2020 Nov 27;477(22):4397-4423. 3. Thiele DL, et, al. The immunosuppressive activity of L-leucyl-L-leucine methyl ester: selective ablation of cytotoxic lymphocytes and monocytes. J Immunol. 1986 Feb 1;136(3):1038-48. |