| Description | GPR88 agonist 2 (compound 53) serves as a potent, brain-penetrant agonist of GPR88, exhibiting an EC50 of 14 µM in the GPR88 cAMP functional assay [1]. |
| In vitro | GPR88激动剂2在WT小鼠纹状体膜中显著提升了[35S] GTPγS的结合活性（EC50: 8.9 μM），然而对于GPR88 KO小鼠纹状体膜则无效果[1]。 |
| In vivo | GPR88激动剂2（20mg/ml，腹腔注射）展现了显著的血浆浓度峰值（Cmax:1670 ng/mL）和良好的代谢稳定性（T1/2:4.66h, CL:21mL/mg/kg），且其脑组织穿透率符合要求（脑浆比:0.34，Cmax:576 ng/mL），显示出有效的药动学性能[1]。 |
| molecular weight | N/A |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |